RotaC: A web-based tool for the complete genome classification of group A rotaviruses

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ID: 110535
2009
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Abstract
Group A rotaviruses are the most common cause of severe diarrhea in infants and children worldwide and continue to have a major global impact on childhood morbidity and mortality. In recent years, considerable research efforts have been devoted to the development of two new live, orally administered vaccines. Although both vaccines have proven to confer a good protection against severe rotavirus gastroenteritis, these vaccines will have to be screened and may have to be updated regularly to reflect temporal and spatial genotype fluctuations. In this matter, the genetic characterization of circulating and new emerging rotavirus strains will need to be compulsory and accurate. An extended classification system for rotaviruses in which all the 11 genomic RNA segments are used, has been proposed recently. The use of this classification system will help to elucidate the role of gene reassortments in the generation of genetic diversity, host range restriction, co-segregation of certain gene segments, and in adaptation to a new host species. Here we present a web-based tool that can be used for fast rotavirus genotype differentiation of all 11 group A rotavirus gene segments according to the new guidelines proposed by the Rotavirus Classification Working Group (RCWG). With the increasing sequencing efforts that are being conducted around the world to unravel complete rotavirus genomes of human and animal origin, this tool will be of great help to analyze and correctly classify the large amount of new data. The web-based tool is freely available at http://rotac.regatools.be .
Reference Key
maes2009bmcrotac: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Piet Maes;Jelle Matthijnssens;Mustafizur Rahman;Marc Van Ranst;Piet Maes;Jelle Matthijnssens;Mustafizur Rahman;Marc Van Ranst;
Journal bmc microbiology
Year 2009
DOI
doi:10.1186/1471-2180-9-238
URL
http://dx.doi.org/10.1186/1471-2180-9-238
Keywords
Microbiology virology life sciences mycology general biological microscopy parasitology Internet National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't genome genomics / methods* pmid:19930627 pmc2785824 doi:10.1186/1471-2180-9-238 piet maes jelle matthijnssens marc van ranst viral / genetics* genomics / instrumentation* rotavirus / classification* rotavirus infections / virology*

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