Early forms of microtubule-associated protein are strongly expressed in cortical dysplasia

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ID: 110487
1970
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Abstract
We report the enhanced expression of early forms of microtubule-associated proteins (MAPs) in cortical dysplasia in surgical resections from 17 children with intractable epilepsy. Large neurons, which represent one of the characteristic cellular features of cortical dysplasia, showed strong immunoreactivity for MAP1B, as well as the low-molecular-weight isoform of MAP2 (MAP2c). Insitu hybridization with MAP1B antisense riboprobe showed markedly increased hybridization signal intensities in the large neurons, whereas neurons in the normal-appearing cortex and most of the normal-sized neurons in the dysplastic cortex had faint signals. Because MAP2c and MAP1B are early forms of MAPs, which are abundantly expressed in the developing brain and down-regulated in the adult, and are thought to be involved in neuronal outgrowth and plasticity, our results suggest that the structural remodeling of neuronal processes is activated in cortical dysplasia.
Reference Key
yamanouchi1970actaearly Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hideo Yamanouchi;Venita Jay;Hiroshi Otsubo;Makiko Kaga;Laurence E. Becker;Sachio Takashima;Hideo Yamanouchi;Venita Jay;Hiroshi Otsubo;Makiko Kaga;Laurence E. Becker;Sachio Takashima;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/s004010050826
URL
https://link.springer.com/article/10.1007/s004010050826
Keywords
pathology neurosciences

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