Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone

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ID: 110239
2000
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Abstract
Polycystic ovarian syndrome (PCOS) is a complex disorder with multiple abnormalities, including hyperandrogenism, ovulatory dysfunction, and altered gonadotropin secretion. The majority of patients have elevated LH levels in plasma and a persistent rapid frequency of LH (GnRH) pulse secretion, the m …
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Authors Eagleson CA;Gingrich MB;Pastor CL;Arora TK;Burt CM;Evans WS;Marshall JC;;
Journal the journal of clinical endocrinology and metabolism
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11095431
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't adult female luteinizing hormone / blood polycystic ovary syndrome / physiopathology* P.H.S. Clinical Trial body mass index reference values pmid:11095431 doi:10.1210/jcem.85.11.6992 c a eagleson m b gingrich j c marshall 17-alpha-hydroxyprogesterone / blood activity cycles androgen antagonists / pharmacology androgen antagonists / therapeutic use* dehydroepiandrosterone sulfate / blood estradiol / blood flutamide / pharmacology flutamide / therapeutic use* follicle stimulating hormone / blood follicle stimulating hormone / metabolism luteinizing hormone / metabolism* polycystic ovary syndrome / blood polycystic ovary syndrome / drug therapy* thyroxine / blood

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