Understanding the Relationship between Glutathione, TGF-β, and Vitamin D in Combating Mycobacterium tuberculosis Infections

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ID: 110147
2020
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Abstract
Tuberculosis (TB) remains a pervasive global health threat. A significant proportion of the world’s population that is affected by latent tuberculosis infection (LTBI) is at risk for reactivation and subsequent transmission to close contacts. Despite sustained efforts in eradication, the rise of multidrug-resistant strains of Mycobacteriumtuberculosis (M. tb) has rendered traditional antibiotic therapy less effective at mitigating the morbidity and mortality of the disease. Management of TB is further complicated by medications with various off-target effects and poor compliance. Immunocompromised patients are the most at-risk in reactivation of a LTBI, due to impairment in effector immune responses. Our laboratory has previously reported that individuals suffering from Type 2 Diabetes Mellitus (T2DM) and HIV exhibited compromised levels of the antioxidant glutathione (GSH). Restoring the levels of GSH resulted in improved control of M. tb infection. The goal of this review is to provide insights on the diverse roles of TGF- β and vitamin D in altering the levels of GSH, granuloma formation, and clearance of M. tb infection. We propose that these pathways represent a potential avenue for future investigation and development of new TB treatment modalities.
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singh2020journalunderstanding Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mohkam Singh;Charles Vaughn;Kayvan Sasaninia;Christopher Yeh;Devanshi Mehta;Ibrahim Khieran;Vishwanath Venketaraman;Singh, Mohkam;Vaughn, Charles;Sasaninia, Kayvan;Yeh, Christopher;Mehta, Devanshi;Khieran, Ibrahim;Venketaraman, Vishwanath;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9092757
URL
https://www.mdpi.com/2077-0383/9/9/2757/htm
Keywords
Mycobacterium tuberculosis hiv vitamin d tuberculosis glutathione tgf-β

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