Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis

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ID: 110129
2020
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Abstract
Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders. Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring. Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required.
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sade2020journalperinatal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shanny Sade;Tamar Wainstock;Eyal Sheiner;Gali Pariente;Sade, Shanny;Wainstock, Tamar;Sheiner, Eyal;Pariente, Gali;
Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9092768
URL
https://doi.org/10.3390/jcm9092768
Keywords
tuberculosis cesarean delivery placental abruption very low birth weight perinatal outcome infectious morbidity tuberculosis cesarean delivery placental abruption very low birth weight perinatal outcome infectious morbidity

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