Analysis of Transformed Upstream Bioprocess Data Provides Insights into Biological System Variation.

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ID: 108931
2020
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Abstract
In recent years, multivariate data analysis (MVDA) and modeling approaches have found increasing applications for upstream bioprocess studies (e.g., monitoring, development, optimization, scale-up, etc.). Many of these studies look at variations in the concentrations of metabolites and cell-based measurements. However, these measures are subject to system inherent variations (e.g., changes in metabolic activity) but also intentional operational changes. We propose to perform MVDA and modeling on data representative of the underlying biological system operation, i.e., the specific rates, which are per se independent of the scale, operational strategy (e.g., batch, fed-batch) and biomass content. Two industrial case studies are highlighted to showcase the approach: one HEK medium performance comparison study and one CHO scale-up/-down study. It is shown that analyzing processes in this way reveals insights into behavior of the underlying biological system, which cannot to the same degree be deducted from the analysis of concentrations. This article is protected by copyright. All rights reserved.
Reference Key
richelle2020analysisbiotechnology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Richelle, Anne;Lee, Boung Wook;Portela, Rui M C;Raley, Jonathan;von Stosch, Moritz;
Journal biotechnology journal
Year 2020
DOI
10.1002/biot.202000113
URL
Keywords
monitoring development fermentation optimization cultivation multivariate data analysis scale-up quality by design cho hek scale-down

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