Coexisting systemic and organ-specific autoimmunity in MOG-IgG1-associated disorders versus AQP4-IgG+ NMOSD.

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ID: 108642
2020
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Abstract
Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD ( = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.
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kunchok2020coexistingmultiple Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kunchok, Amy;Flanagan, Eoin P;Snyder, Melissa;Saadeh, Ruba;Chen, John J;Weinshenker, Brian G;McKeon, Andrew;Pittock, Sean J;
Journal multiple sclerosis (houndmills, basingstoke, england)
Year 2020
DOI
10.1177/1352458520933884
URL
Keywords
autoimmunity humoral immunity aqp4-igg neuromyelitis optica spectrum disorder mog-igg-associated disorders systemic lupus erythematous

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