Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?

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ID: 107756
2020
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Abstract
SARS-CoV-2 or COVID-19 is representing the major global burden that implicated more than 4.7 million infected cases and 310 thousand deaths worldwide in less than 6 months. The prevalence of this pandemic disease is expected to rise every day. The challenge is to control its rapid spread meanwhile looking for a specific treatment to improve patient outcomes. Hesperidin is a classical herbal medicine used worldwide for a long time with an excellent safety profile. Hesperidin is a well-known herbal medication used as an antioxidant and anti-inflammatory agent. Available shreds of evidence support the promising use of hesperidin in prophylaxis and treatment of COVID 19. Herein, we discuss the possible prophylactic and treatment mechanisms of hesperidin based on previous and recent findings. Hesperidin can block coronavirus from entering host cells through ACE2 receptors which can prevent the infection. Anti-viral activity of hesperidin might constitute a treatment option for COVID-19 through improving host cellular immunity against infection and its good anti-inflammatory activity may help in controlling cytokine storm. Hesperidin mixture with diosmin co-administrated with heparin protect against venous thromboembolism which may prevent disease progression. Based on that, hesperidin might be used as a meaningful prophylactic agent and a promising adjuvant treatment option against SARS-CoV-2 infection.
Reference Key
haggag2020ismedical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Haggag, Yusuf A;El-Ashmawy, Nahla E;Okasha, Kamal M;
Journal medical hypotheses
Year 2020
DOI
S0306-9877(20)31358-X
URL
Keywords
treatment immunity prophylaxis covid-19 sars-cov-2 anti-viral activity hesperidin viral entry

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