Nebulized Lidocaine in COVID-19, An Hypothesis.
Clicks: 218
ID: 107403
2020
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Abstract
Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients' lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
| Reference Key |
ali2020nebulizedmedical
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|---|---|
| Authors | Ali, Ziad A;El-Mallakh, Rif S; |
| Journal | medical hypotheses |
| Year | 2020 |
| DOI |
S0306-9877(20)31293-7
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| URL | |
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