EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.

Clicks: 384
ID: 1072
2003
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Abstract
EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC50 value of 3.9 microM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with an IC50 value of 5.2 microM.
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koizumi2003ei-2346, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Koizumi, Fumito;Hasegawa, Atsuhiro;Ochiai, Keiko;Ando, Katsuhiko;Kondo, Hidemasa;Yoshida, Mayumi;Matsuda, Yuzuru;Nakanishi, Satoshi;
Journal the journal of antibiotics
Year 2003
DOI
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