EI-2346, a novel interleukin-1beta converting enzyme inhibitor produced by Streptomyces sp. E-2346. I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.

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ID: 1072
2003
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Abstract
EI-2346, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC50 value of 3.9 microM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with an IC50 value of 5.2 microM.
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koizumi2003ei-2346, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fumito Koizumi, Atsuhiro Hasegawa, Keiko Ochiai, Katsuhiko Ando, Hidemasa Kondo, Mayumi Yoshida, Yuzuru Matsuda, Satoshi Nakanishi
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Journal the journal of antibiotics
Year 2003
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