Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities.

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ID: 1071
2003
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Abstract
Novel antibiotics named kigamicin A, B, C, D, and E were discovered from the culture broth of Amycolatopsis sp. ML630-mF1 by their selective killing activity against PANC-1 cells only under a nutrient starved condition. Under a condition of nutrient starvation, kigamicins A, B, C, and D inhibited PANC-1 cell survival at 100 times lower concentration than in normal culture. Kigamicins showed antimicrobial activity against Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Kigamicin D inhibited the growth of various mouse tumor cell lines at IC50 of about 1 microg/ml.
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kunimoto2003kigamicins, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kunimoto, Setsuko;Lu, Jie;Esumi, Hiroyasu;Yamazaki, Yohko;Kinoshita, Naoko;Honma, Yoshiko;Hamada, Masa;Ohsono, Michiyo;Ishizuka, Masaaki;Takeuchi, Tomio;
Journal the journal of antibiotics
Year 2003
DOI
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