Ameliorates Bone Loss in Ovariectomized Mice and Inhibits Osteoclastogenesis In Vitro.

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ID: 106997
2020
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Abstract
Estrogen deprivation in postmenopausal women causes disruption of bone homeostasis, resulting in bone loss and osteoporosis. Conventional therapies can exert adverse effects. The sclerotum of has been used in traditional medicine and as a nutritional supplement and to treat various diseases. However, the effects of on the bone remain largely undetermined. In this study, we examined the effects of hydroethanolic extract (PC) on osteoclast differentiation and estrogen-deprivation-induced bone loss in an ovariectomized mouse model of postmenopausal osteoporosis. PC-mediated inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation and resorption activity suppressed RANKL-induced expression of nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which is a crucial transcription factor for osteoclast differentiation. In ovariectomized mice, PC markedly alleviated trabecular bone loss and reduced the accumulation of lipid droplets in the bone marrow. We additionally identified ten triterpenoid constituents of PC using UPLC-MS/MS analysis. Our results indicate that PC negatively regulated osteoclast differentiation and function, and can potentially be used to manage postmenopausal osteoporosis.
Reference Key
hwang2020nutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hwang, Youn-Hwan;Jang, Seon-A;Lee, Ami;Kim, Taesoo;Ha, Hyunil;
Journal Nutrients
Year 2020
DOI
E1383
URL
Keywords
menopause osteoporosis poria cocos osteoclast ovariectomy

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