Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence—A Single Institution Long-Term Follow-up Study

Clicks: 353
ID: 10649
2019
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Abstract
Objectives. This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall. Methods. This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry. The Kaplan-Meier method was used to estimate OS and LRFR. Multivariate Cox analyses were used to determine prognostic factors for OS and LRFR. Results. The 5-year OS was 55% (95% confidence interval (CI): 0.44-0.65) and 5-year LRFR was 77% (95% CI: 0.67-0.85). High malignancy grade and intralesional/marginal resection were identified as negative predictors for OS. High grade was the only prognostic factor associated with a lower LRFR. Conclusions. In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence.
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rytter2019softinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Soerensen, Tine Rytter;Raedkjaer, Mathias;Jørgensen, Peter Holmberg;Hoejsgaard, Anette;Safwat, Akmal;Baad-Hansen, Thomas;Soerensen, Tine Rytter;Raedkjaer, Mathias;Jørgensen, Peter Holmberg;Hoejsgaard, Anette;Safwat, Akmal;Baad-Hansen, Thomas;
Journal international journal of surgical oncology
Year 2019
DOI
10.1155/2019/2350157
URL
https://www.hindawi.com/journals/ijso/2019/2350157/abs/
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