Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

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ID: 104732
2020
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Abstract
The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and FljB, are methylated at surface-exposed lysine residues by FliB. A Salmonella Typhimurium mutant deficient in flagellin methylation is outcompeted for gut colonization in a gastroenteritis mouse model, and methylation of flagellin promotes bacterial invasion of epithelial cells in vitro. Lysine methylation increases the surface hydrophobicity of flagellin, and enhances flagella-dependent adhesion of Salmonella to phosphatidylcholine vesicles and epithelial cells. Therefore, posttranslational methylation of flagellin facilitates adhesion of Salmonella Typhimurium to hydrophobic host cell surfaces, and contributes to efficient gut colonization and host infection.
Reference Key
horstmann2020methylationnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Horstmann, Julia A;Lunelli, Michele;Cazzola, Hélène;Heidemann, Johannes;Kühne, Caroline;Steffen, Pascal;Szefs, Sandra;Rossi, Claire;Lokareddy, Ravi K;Wang, Chu;Lemaire, Laurine;Hughes, Kelly T;Uetrecht, Charlotte;Schlüter, Hartmut;Grassl, Guntram A;Stradal, Theresia E B;Rossez, Yannick;Kolbe, Michael;Erhardt, Marc;
Journal Nature communications
Year 2020
DOI
10.1038/s41467-020-15738-3
URL
Keywords
incidence recurrence antitubercular agents/therapeutic use* south africa/epidemiology tuberculosispulmonary/epidemiology

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