Impact of cognitive reserve on clinical and neuropsychological measures in patients with mild cognitive impairment.

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ID: 103584
2020
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Abstract
Cognitive reserve influences age of onset, speed of progression, and clinical manifestations of Alzheimer's disease. We investigated whether cognitive reserve interacts with clinical and neuropsychological parameters in mild cognitive impairment (MCI).In this cross-sectional study, we recruited 273 people (70.6 ± 10.1 years, 54.6% women) suffering from subjective memory complaints ( = 65), MCI ( = 121), or dementia ( = 87). Patients underwent neuropsychological evaluation, laboratory testing, and brain imaging. Additionally, we obtained information on years of education and help-seeking motivation.MCI patients with a university degree were significantly older than those without (71.6 ± 9.6 vs. 66.9 ± 10.3, = 0.02). University-educated MCI patients demonstrated superior performance in verbal fluency. Intrinsic help-seeking motivation (self-referral) was associated with higher cognitive reserve. Female MCI patients presented with greater intrinsic motivation.Cognitive reserve modulates clinical and neuropsychological measures in patients with MCI.
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haussmann2020impactaustralasian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Haussmann, Robert;von Lieres Und Wilkau, Amrei F E;Sauer, Cathrin;Nilles, Fabienne;Donix, Markus;
Journal australasian psychiatry : bulletin of royal australian and new zealand college of psychiatrists
Year 2020
DOI
10.1177/1039856220908171
URL
Keywords
dementia mild cognitive impairment intelligence educational attainment cognitive reserve

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