Low Rates of Retesting for Eradication of Helicobacter pylori Infection After Treatment in the Veterans Health Administration.

Niedrige Raten an Nachtestungen auf Eradikation einer Helicobacter-pylori-Infektion nach Behandlung in der Veterans Health Administration.

Baixas Taxas de Reteste para Erradicação da Infecção por *Helicobacter pylori* Após o Tratamento na Veterans Health Administration.

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ID: 103307
2020
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Abstract
Expert consensus mandates retesting for eradication of Helicobacter pylori infection after treatment, but it is not clear how many patients are actually retested. We evaluated factors associated with retesting for H pylori in a large, nationwide cohort.We performed a retrospective cohort study of patients with H pylori infection (detected by urea breath test, stool antigen, or pathology) who were prescribed an eradication regimen from January 1, 1994 through December 31, 2018 within the Veterans Health Administration (VHA). We collected data on demographic features, smoking history, socioeconomic status, facility poverty level and academic status, and provider specialties and professions. The primary outcome was retesting for eradication. Statistical analyses included mixed-effects logistic regression.Of 27,185 patients prescribed an H pylori eradication regimen, 6486 patients (23.9%) were retested. Among 7623 patients for whom we could identify the provider who ordered the test, 2663 patients (34.9%) received the order from a gastroenterological provider. Female sex (odds ratio, 1.22; 95% CI, 1.08-1.38; P=.002) and history of smoking (odds ratio, 1.24; 95% CI, 1.15-1.33; P<.001) were patient factors associated with retesting. There was an interaction between method of initial diagnosis of H pylori infection and provider who ordered the initial test (P<.001). There was significant variation in rates of retesting among VHA facilities (P<.001).In an analysis of data from a VHA cohort of patients with H pylori infection, we found low rates of retesting after eradication treatment. There is significant variation in rates of retesting among VHA facilities. H pylori testing is ordered by non-gastroenterology specialists two-thirds of the time. Confirming eradication of H pylori is mandatory and widespread quality assurance protocols are needed.
Der Expertenkonsens schreibt eine Eradikationskontrolle nach der Behandlung einer Infektion mit Helicobacter pylori vor, es ist jedoch unklar, wie viele Patienten tatsächlich nachgetestet werden. Wir untersuchten Faktoren, die mit einer erneuten Testung auf H. pylori in einer großen, landesweiten Kohorte assoziiert sind. Wir führten eine retrospektive Kohortenstudie an Patienten mit einer H.-pylori-Infektion durch (nachgewiesen mittels Harnstoff-Atemtest, Stuhlantigentest oder Pathologie), denen zwischen dem 1. Januar 1994 und dem 31. Dezember 2018 innerhalb der Veterans Health Administration (VHA) ein Eradikationsschema verschrieben wurde. Wir erfassten Daten zu demografischen Merkmalen, Raucheranamnese, sozioökonomischem Status, Armutsniveau und akademischem Status der Einrichtung sowie Fachrichtungen und Berufsgruppen der Leistungserbringer. Der primäre Endpunkt war die Durchführung einer Eradikationskontrolle. Die statistischen Analysen umfassten gemischte logistische Regressionsmodelle. Von 27.185 Patienten, denen ein H.-pylori-Eradikationsschema verschrieben wurde, wurden 6.486 Patienten (23,9 %) nachgetestet. Unter den 7.623 Patienten, bei denen der anordnende Leistungserbringer identifiziert werden konnte, erfolgte die Veranlassung bei 2.663 Patienten (34,9 %) durch einen gastroenterologischen Behandler. Weibliches Geschlecht (Odds Ratio: 1,22; 95%-KI: 1,08–1,38; P = 0,002) und eine Raucheranamnese (Odds Ratio: 1,24; 95%-KI: 1,15–1,33; P < 0,001) waren patientenseitige Faktoren, die mit einer Nachtestung assoziiert waren. Es zeigte sich eine Interaktion zwischen der Methode der Erstdiagnose der H.-pylori-Infektion und dem Leistungserbringer, der den initialen Test anordnete (P < 0,001). Zudem bestanden signifikante Varianzen bei den Nachtestungsraten zwischen den einzelnen VHA-Einrichtungen (P < 0,001). In einer Analyse von Daten aus einer VHA-Kohorte von Patienten mit H.-pylori-Infektion stellten wir niedrige Raten an Kontrolluntersuchungen nach einer Eradikationstherapie fest. Die Raten der Nachtestungen variieren zwischen den VHA-Einrichtungen signifikant. Die H.-pylori-Testung wird in zwei Dritteln der Fälle von Nicht-Gastroenterologen angeordnet. Die Bestätigung der Eradikation von H. pylori ist obligatorisch, und flächendeckende Qualitätssicherungsprotokolle sind erforderlich.
O consenso de especialistas preconiza a realização de novo teste para confirmar a erradicação da infecção por *Helicobacter pylori* após o tratamento, mas não está claro quantos pacientes são de fato retestados. Avaliamos os fatores associados à retestagem para *H. pylori* em uma ampla coorte de âmbito nacional. Realizamos um estudo de coorte retrospectivo com pacientes com infecção por *H. pylori* (detectada por teste respiratório com ureia, antígeno fecal ou exame anatomopatológico) aos quais foi prescrito um esquema de erradicação entre 1º de janeiro de 1994 e 31 de dezembro de 2018 no âmbito da Veterans Health Administration (VHA). Coletamos dados sobre características demográficas, histórico de tabagismo, nível socioeconômico, nível de pobreza e status acadêmico da instituição de saúde, além de especialidades e categorias profissionais dos médicos solicitantes. O desfecho primário foi a retestagem para confirmação da erradicação. As análises estatísticas incluíram regressão logística de efeitos mistos. Dos 27.185 pacientes aos quais foi prescrito um esquema de erradicação de *H. pylori*, 6.486 pacientes (23,9%) foram retestados. Entre os 7.623 pacientes para os quais foi possível identificar o profissional que solicitou o teste, 2.663 pacientes (34,9%) receberam o pedido de um especialista em gastroenterologia. Sexo feminino (razão de chances, 1,22; IC 95%, 1,08–1,38; P = 0,002) e histórico de tabagismo (razão de chances, 1,24; IC 95%, 1,15–1,33; P < 0,001) foram fatores ligados ao paciente associados à retestagem. Houve interação entre o método do diagnóstico inicial da infecção por *H. pylori* e o profissional que solicitou o teste inicial (P < 0,001). Houve variação significativa nas taxas de retestagem entre as unidades da VHA (P < 0,001). Em uma análise de dados de uma coorte da VHA de pacientes com infecção por *H. pylori*, encontramos baixas taxas de retestagem após o tratamento de erradicação. Há uma variação significativa nas taxas de retestagem entre as unidades da VHA. O teste para *H. pylori* é solicitado por profissionais não gastroenterologistas em dois terços das vezes. Confirmar a erradicação do *H. pylori* é mandatório, sendo necessária a implementação ampla de protocolos de garantia da qualidade.
专家共识明确要求在治疗后对幽门螺杆菌(*H pylori*)感染的根除情况进行复查,但目前尚不清楚实际接受复查的患者比例。我们在一项大规模全国性队列中评估了与幽门螺杆菌复查相关的因素。我们对1994年1月1日至2018年12月31日期间在退伍军人卫生管理局(VHA)系统内开具根除方案处方的幽门螺杆菌感染患者(经尿素呼气试验、粪便抗原或病理学检查确诊)进行了一项回顾性队列研究。我们收集了人口学特征、吸烟史、社会经济状况、医疗机构所在地区贫困水平和学术资质,以及医疗提供者的专业与职业背景等数据。主要结局指标为根除复查。统计分析采用混合效应Logistic回归。在27,185例处方了幽门螺杆菌根除方案的患者中,有6,486例(23.9%)接受了复查。在能够确定开单医生的7,623例患者中,有2,663例(34.9%)的医嘱由消化科医疗提供者开具。女性(比值比 [OR],1.22;95% CI,1.08–1.38;*P* = .002)和吸烟史(OR,1.24;95% CI,1.15–1.33;*P* < .001)是与复查相关的患者因素。幽门螺杆菌感染的初次诊断方法与开具初次检测医嘱的医疗提供者之间存在交互作用(*P* < .001)。不同VHA医疗机构之间的复查率存在显著差异(*P* < .001)。在对VHA幽门螺杆菌感染患者队列的数据分析中,我们发现根除治疗后的复查率偏低。各VHA机构间的复查率差异显著。三分之二的幽门螺杆菌检测由非消化专科医生开具。确认幽门螺杆菌根除情况是必须遵循的临床规范,亟需推行广泛的质量保证方案。
Reference Key
kumar2020lowclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kumar, Shria;Metz, David C;Kaplan, David E;Goldberg, David S;
Journal clinical gastroenterology and hepatology : the official clinical practice journal of the american gastroenterological association
Year 2020
DOI
S1542-3565(20)30436-5
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