SARS-CoV-2, COVID-19 and inherited arrhythmia syndromes.

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ID: 102935
2020
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Abstract
Ever since the first case was reported at the end of 2019, the SARS-COV-2 virus and associated lung disease COVID-19 has spread throughout the world and has become a pandemic. In particular, the high transmission rate of the virus has made it a threat to public health globally. Currently, there is no proven effective therapy against the virus, and the impact on other diseases is also uncertain, especially inherited arrhythmia syndrome. Arrhythmogenic effect of COVID-19 can be expected, potentially contributing to disease outcome. This may be of importance for patients with an increased risk for cardiac arrhythmias, either secondary to acquired conditions or co-morbidities or consequent to inherited syndromes. Management of patients with inherited arrhythmia syndromes such as Long QT syndrome, Brugada syndrome, Short QT syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia in the setting of the COVID-19 pandemic may prove particularly challenging. Depending on the inherited defect involved, these patients may be susceptible to pro-arrhythmic effects of COVID-19-related issues such as fever, stress, electrolyte disturbances and use of antiviral drugs. We here describe the potential COVID-19 associated risks and therapeutic considerations for patients with distinct inherited arrhythmia syndromes and provide recommendations, pending local possibilities, for their monitoring and management during this pandemic.
Reference Key
wu2020sarscov2heart Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wu, Cheng-I;Postema, Pieter G;Arbelo, Elena;Behr, Elijah R;Bezzina, Connie R;Napolitano, Carlo;Robyns, Tomas;Probst, Vincent;Schulze-Bahr, Eric;Remme, Carol Ann;Wilde, Arthur A M;
Journal heart rhythm
Year 2020
DOI
S1547-5271(20)30285-X
URL
Keywords
long qt syndrome covid-19 sars-cov-2 brugada syndrome catecholaminergic polymorphic ventricular tachycardia short qt syndrome

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