Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities

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ID: 102302
2019
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Abstract
Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia.
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Authors Migliavacca, Eugenia;Tay, Stacey K. H.;Patel, Harnish P.;Sonntag, Tanja;Civiletto, Gabriele;McFarlane, Craig;Forrester, Terence;Barton, Sheila J.;Leow, Melvin K.;Antoun, Elie;Charpagne, Aline;Chong, Yap Seng;Descombes, Patrick;Feng, Lei;Francis-Emmanuel, Patrice;Garratt, Emma S.;Giner, Maria Pilar;Green, Curtis O.;Karaz, Sonia;Kothandaraman, Narasimhan;Marquis, Julien;Metairon, Sylviane;Moco, Sofia;Nelson, Gail;Ngo, Sherry;Pleasants, Tony;Raymond, Frederic;Sayer, Avan A.;Sim, Chu Ming;Slater-Jefferies, Jo;Syddall, Holly E.;Tan, Pei Fang;Titcombe, Philip;Vaz, Candida;Westbury, Leo D.;Wong, Gerard;Yonghui, Wu;Cooper, Cyrus;Sheppard, Allan;Godfrey, Keith M.;Lillycrop, Karen A.;Karnani, Neerja;Feige, Jerome N.;
Journal Nature communications
Year 2019
DOI
DOI not found
URL
http://link.springer.com/article/10.1038/s41467-019-13694-1
Keywords
Technology (General) Science business petroleum refining. petroleum products management. industrial management fine arts

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