A Case-Based Approach to New Directions in Dietary Therapy of Crohn's Disease: Food for Thought.

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ID: 101883
2020
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Abstract
Recent evidence has demonstrated that Crohn's disease may have its roots in dysbiosis of the microbiome and other environmental factors. One of the strongest risk factors linked to immune activation appears to be diet. Exclusion diets have been shown to ameliorate inflammation and induce remission in 70-80% of treatment-naïve children at disease onset, and to induce remission in patients that lose response or are refractory to currently recommended medical therapy. Recent studies have also linked dietary modulation of the microbiome with clinical remission, while reintroduction of the previous habitual diet led to reactivation of inflammation and reversion of the dysbiotic state. While dietary therapy has usually been used as a first line therapy as a bridge to immunomodulators, newer insights suggest that new treatment paradigms involving dietary therapy may allow different treatment strategies. This case-based narrative review will discuss the Crohn's disease exclusion diet (CDED) as monotherapy, combination therapy with drugs, as a rescue therapy in refractory patients and for de-escalation from medical therapy.
Reference Key
levine2020anutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Levine, Arie;El-Matary, Wael;Van Limbergen, Johan;
Journal Nutrients
Year 2020
DOI
E880
URL
Keywords
diet treatment crohn’s disease inflammatory bowel disease microbiome crohn’s disease exclusion diet (cded)

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