FAM13A affects body fat distribution and adipocyte function.

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ID: 100847
2020
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Abstract
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.
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fathzadeh2020fam13anature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fathzadeh, Mohsen;Li, Jiehan;Rao, Abhiram;Cook, Naomi;Chennamsetty, Indumathi;Seldin, Marcus;Zhou, Xiang;Sangwung, Panjamaporn;Gloudemans, Michael J;Keller, Mark;Attie, Allan;Yang, Jing;Wabitsch, Martin;Carcamo-Orive, Ivan;Tada, Yuko;Lusis, Aldons J;Shin, Myung Kyun;Molony, Cliona M;McLaughlin, Tracey;Reaven, Gerald;Montgomery, Stephen B;Reilly, Dermot;Quertermous, Thomas;Ingelsson, Erik;Knowles, Joshua W;
Journal Nature communications
Year 2020
DOI
10.1038/s41467-020-15291-z
URL
Keywords
detection molecular epidemiology respiratory disease farmed snakes ferlavirus

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