High HbA level is correlated with blood-brain barrier disruption in syphilis patients.

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ID: 100377
2020
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Ranked #9 of 38 articles by views in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

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Abstract
Diabetes mellitus (DM) and neurosyphilis (NS) may both damage the blood-brain barrier (BBB). It seems that non-neurosyphilis (non-NS) patients with high HbA levels are likely to develop into NS. However, the correlation of HbA level with BBB disruption in syphilis (non-NS) patients is unclear. In this study, we used dynamic contrast-enhanced (DCE) MRI to quantify regional BBB permeability in syphilis (non-NS) patients and detected several molecular biomarkers of cerebrospinal fluid (CSF). We found that BBB permeability values in the hippocampus, white matter, and cortex inferior temporal gyrus were correlated with albumin quotient (Qalb), CSF concentrations of interleukin IL-6 and IL-10. Moreover, BBB breakdown in white matter was correlated with CSF concentrations of sICAM-1 and sVCAM-1. In conclusion, our data suggest that BBB integrity may be liable to be disrupted in syphilis (non-NS) patients, patients with high HbA levels, as well as syphilis (non-NS) patients with high HbA levels, and it is particularly important to control blood glucose in these patients.
Reference Key
wang2020highneurological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Feng;Ge, Hua;Su, Xinhui;Wang, Ru;Zeng, Jianqi;Miao, Jiayin;
Journal Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Year 2020
DOI
10.1007/s10072-019-04031-x
URL
Keywords
hba1c blood-brain barrier permeability non-neurosyphilis

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