Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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ID: 117390
2001
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Abstract
The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1alpha [HNF1alpha], -1beta, -3alpha, -3beta, -3gamma, -4alpha, and -6 and members of the c/eb ā€¦
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Authors Hayhurst GP;Lee YH;Lambert G;Ward JM;Gonzalez FJ;;
Journal molecular and cellular biology
Year 2001
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11158324
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine phenotype Receptors Transcription Factors / metabolism* Base Sequence Active Y H Lee Liver / metabolism* Knockout cell differentiation lipid metabolism* transcription factors / genetics homeostasis gene expression* dna-binding proteins* pmid:11158324 pmc99591 doi:10.1128/mcb.21.4.1393-1403.2001 g p hayhurst f j gonzalez basic helix-loop-helix leucine zipper transcription factors bile acids and salts / metabolism biological transport dna primers / genetics gene targeting hepatocyte nuclear factor 4 hepatomegaly / genetics hepatomegaly / pathology lipids / blood liver / cytology liver glycogen / metabolism phosphoproteins / genetics phosphoproteins / metabolism* cytoplasmic and nuclear / genetics

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