diagnostic value of e-cadherin and fibronectin in differentiation between reactive mesothelial and adenocarcinoma cells in serous effusions

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2012
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摘要
Background: One of the problems in studying serous effusion cytological samples is differentiation of reactive mesothelial cells from metastatic adenocarcinoma cells. Materials and Methods: In this study, the immunohistochemical diagnostic value of E-cadherin and fibronectin markers for differentiation of these 2 groups of cells was studied. 50 cell block samples prepared from serous effusions were examined. Based on clinical and histological studies, 25 cases had primary carcinoma, and the other 25 were proved to be benign effusion cases. All the cases were studied for E-cadherin and fibronectin immunostaining using an envision technique. Statistical analyzes were performed employing Chi-square and exact Fisher tests, using SPSS software (version 16). Results: 24 of the 25 benign cases were stained with fibronectin and 2 with E-cadherin, whereas from among the 25 metastatic cases, 2 reacted to fibronectin and 22 to E-cadherin. Considering the staining of the 2 markers under conditions that the cells were stained with fibronectin but not with E-cadherin, positive predictive value (PPV) and negative predictive value (NPV) to identify reactive mesothelial cells were 100% and 92.5% while under conditions that had not been stained with fibronectin but with E-cadherin, PPV and NPV to detect adenocarcinoma cells were 95.2% and 82.1%, respectively. Conclusion: Employing this short panel can be helpful for better differentiation of adenocarcinoma and reactive mesothelial cells in serous fluids.
参考键
moghaddam2012advanceddiagnostic 使用此键在稿件中自动引用，同时使用 SciMatic 稿件管理器或论文管理器
作者 ;Noushin Afshar Moghaddam;Reza Tahririan;Mehdi Eftekhari;Dana Tahririan;Alireza Rahmani
期刊 microbiological research
年份 2012
DOI
10.4103/2277-9175.100173
URL
http://www.advbiores.net/article.asp?issn=2277-9175;year=2012;volume=1;issue=1;spage=56;epage=56;aulast=Moghaddam
关键词
immunohistochemistry fibronectin adenocarcinoma

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