mucoadhesive formulation of bidens pilosa l. (asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice

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ID: 161994
2015
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摘要
Gastrointestinal mucositis induced during cancer treatment is considered a serious dose-limiting side effect of chemotherapy and/or radiotherapy. Frequently, interruption of the cancer treatment due to this pathology leads to a reduction in cure rates, increase of treatment costs and decrease life quality of the patient. Natural products such as Bidens pilosa L. (Asteraceae), represent a potential alternative for the treatment of mucositis given its anti-inflammatory properties. In this study, B. pilosa glycolic extract was formulated (BPF) with poloxamer, a mucoadhesive copolymer, was used for treatment of 5-fluorouracil (5-FU)-induced mucositis in mice. As expected, animals only treated with 5-FU (200 mg/kg) presented marked weight loss, reduction of intestinal villi, crypts and muscular layer, which was associated with severe disruption of crypts, edema, inflammatory infiltrate and vacuolization in the intestinal tissue, as compared to the control group and healthy animals only treated with BPF. On the other hand, the treatment of intestinal mucositis-bearing mice with BPF (75, 100 or 125 mg/kg) managed to mitigate clinical and pathologic changes, noticeably at 100 mg/kg. This dose led to the restoration of intestinal proliferative activity through increasing Ki-67 levels; modulated the expression of Bax, Bcl2 and p53 apoptotic markers protecting intestinal cells from cell death. Moreover, this treatment regulated lipid peroxidation and inflammatory infiltration. No acute toxic effects were observed with this formulation. This work demonstrated that BPF was safe and effective against 5-FU-induced intestinal mucositis in mice. Additional studies are already in progress to further characterize the mechanisms involved in the protective effects of this technological formulation toward the development of a new medicine for the prevention and treatment of intestinal injury in patients undergoing chemotherapy/radiotherapy.
参考键
vila2015toxicologymucoadhesive 使用此键在稿件中自动引用，同时使用 SciMatic 稿件管理器或论文管理器
作者 ;Paulo Henrique Marcelino de Ávila;Renato Ivan de Ávila;Edvande Xavier dos Santos Filho;Carla Caroline Cunha Bastos;Aline Carvalho Batista;Elismauro Francisco Mendonça;Raphael Caixeta Serpa;Ricardo Neves Marreto;Andrezza Furquim da Cruz;Eliana Martins Lima;Marize Campos Valadares
期刊 international journal of systematic and evolutionary microbiology
年份 2015
DOI
10.1016/j.toxrep.2015.03.003
URL
http://www.sciencedirect.com/science/article/pii/S2214750015000359
关键词
Chemotherapy 5-fluorouracil mucositis poisons

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