cooperativity

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T-495, a novel low cooperative M receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk.
Mandai, Takao;Sako, Yuu;Kurimoto, Emi;Shimizu, Yuji;Nakamura, Minoru;Fushimi, Makoto;Maeda, Ryouta;M...
2020 pharmacology research & perspectives DOI: 10.1002/prp2.560 217 views
2
Rationalizing Tight Ligand Binding through Cooperative Interaction Networks
Bernd Kuhn,Julian E. Fuchs,Michael Reutlinger,Martin Stahl,Neil R. Taylor;Bernd Kuhn;Julian E. Fuchs...
2011 Journal of chemical information and modeling DOI: 10.1021/ci200319e 208 views

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pharmacology research & perspectives
ISSN: 2052-1707 453 views

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α-synuclein m1 muscarinic acetylcholine receptor positive allosteric modulator structure protein treatment interactions optimization function ligand interaction networks rationalization