central nervous system agents in medicinal chemistry

[1] the hsp90 co-chaperones sti1, aha1, and p23 regulate adaptive responses to antifungal azoles

[2] Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.

[3] Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples.

[4] Selective Synthesis of 3-(9 H-Carbazol-2-yl)indolin-2-ones and Spiro[tetrahydrocarbazole-3,3'-oxindoles] via a HOTf Catalyzed Three-Component Reaction.

[5] Synthesis and properties of blue luminescent bipolar materials constructed with carbazole and anthracene units with 4-cyanophenyl substitute at the 9-position of the carbazole unit.

[6] Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.

[7] Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.

[8] Synthesis of hetero annulated isoxazolo-, pyrido- and pyrimido carbazoles: Screened for in vitro antitumor activity and structure activity relationships, a novel 2-amino-4-(3'-bromo-4'-methoxyphenyl)-8-chloro-11H-pyrimido[4,5-a]carbazole as an antitumor agent.

[9] Luminescence and electronic structure of Nd³⁺ complex with pyrazole-substituted 1,3-diketone and 1,10-phenanthroline

[10] One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1 H -imidazoles in the Presence of a Molecular Sieve Supported Titanium Catalyst under Mild Basic Conditions

[11] Synthesis and Characterization of Fluorine-Containing Polybenzoxazoles by High-Temperature Direct Polycondensation

[12] Benzimidazobenzothiazole-Based Bipolar Hosts to Harvest Nearly All of the Excitons from Blue Delayed Fluorescence and Phosphorescent Organic Light-Emitting Diodes.

[13] Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives

[14] Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physico-chemical properties

[15] Biological activities and in silico physico-chemical properties of 1,2,3-triazoles derived from natural bioactive alcohols

[16] Organically Modified Silica with Pyrazole-3-carbaldehyde as a New Sorbent for Solid-Liquid Extraction of Heavy Metals

[17] A Novel Synthesis of Aryl- and Heteroaryl - Annulated Carbazoles: Newly Synthesized Pyrido-, Benzo[a]- and Spirooxindolinebenzo[a]-carbazols

[18] Electrochemical synthesis and electrochromic properties of new conjugated polycarbazoles from di(carbazol-9-yl)-substituted triphenylamine and N-phenylcarbazole derivatives

[19] PhI(OAc) <inf>2</inf> -Mediated One-Pot Synthesis and their Antibacterial Activity of Flavone and Coumarin Based Isoxazoles Under Mild Reaction Conditions

[20] A novel method for synthesis and their antimicrobial activity of 1H-tetrazole based flavones and flavanone derivatives under ultrasonic and microwave irradiation methods

[21] Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents

[22] Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans

[23] Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [F]-radiolabeling and PET study in rats.

[24] Tweaking the proton transfer triggered proton transfer of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole.

[25] Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.

[26] Development of a new stability indicating method for the simultaneous separation of voriconazole from its impurities along with sodium benzoate used as a preservative in a powder for oral suspension.

[27] Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

[28] Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators.

[29] Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.

[30] Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies.

[31] Toward Rational Design of Novel Anti-Cancer Drugs Based on Targeting, Solubility, and Bioavailability Exemplified by 1,3,4-Thiadiazole Derivatives Synthesized Under Solvent-Free Conditions.

[32] Emission Properties of Diblock Copolymers Composed of Poly(ethylene glycol) and Dense 1,2,3-Triazole Blocks.

[33] Nickel-Catalyzed Coupling of N-Sulfonyl-1,2,3-triazole with H-Phosphine Oxides: Stereoselective and Site-Selective Synthesis of α-Aminovinylphosphoryl Derivatives.

[34] Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

[35] Downsizing of robust Fe-triazole@SiO spin-crossover nanoparticles with ultrathin shells.

[36] Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors.

[37] Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination.

[38] Hg induced hydrolysis of thiazole amine based Schiff base: Colorimetric and fluorogenic chemodosimeter for Hg ions in an aqueous medium.

[39] Triazole-appended pyrano[2,3-: C] pyrazolone based colorimetric chemosensors for recognition of Fe³⁺ ions and their molecular logic gate behavior

[40] Pyridino-18-crown-6 ether type chemosensors containing a benzothiazole fluorophore unit: Synthesis and enantiomeric recognition studies

[41] Colorimetric N-butyl-3,6-diamidecarbazole-based chemosensors for detection of fluoride and cyanide anions

[42] Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism.

[43] 1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.

[44] Antibacterial activity study of 1,2,4-triazole derivatives.

[45] Parameters that determine dissolution and efficacy of itraconazole and its relevance to recalcitrant dermatophytoses.

[46] Current advances of triazole alcohols derived from fluconazole: Design, in vitro and in silico studies.

[47] Biological Significance of Imidazole-Based Analogues in New Drug Development.

[48] Why do lung transplant patients discontinue triazole prophylaxis?

[49] Exploring the chemistry and therapeutic potential of triazoles: A comprehensive literature review.

[50] Polymer-Bound 4-Pyridyl-5-hydroxyethyl-thiazole Fluorescent Chemosensors for the Detection of Organophosphate Nerve Agent Simulants.

[51] Anthraimidazoledione Based Reversible and Reusable Selective Chemosensors for Fluoride Ion: Naked-Eye, Colorimetric and Fluorescence “ON-OFF”

[52] Two-dimensional carbazole-based derivatives as versatile chemosensors for colorimetric detection of cyanide and two-photon fluorescence imaging of viscosity in vitro

[53] Conjugated microporous polymer-based carbazole derivatives as fluorescence chemosensors for picronitric acid

[54] catena-Poly[[aqua(imidazole)cadmium(II)]-&amp;#956;3-benzene-1,3-dicarboxylato]

[55] Light-Responsive Arylazopyrazole Gelators: From Organic to Aqueous Media and from Supramolecular to Dynamic Covalent Chemistry

[56] Bis(benzimidazole) as supramolecular building block in manganese(IV) chemistry

[57] Two novel bipolar hosts based on 1,2,4-triazole derivatives for highly efficient red phosphorescent OLEDs showing a small efficiency roll-off

[58] Novel Ir(III) complexes ligated with 2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole for highly efficient OLEDs with mild efficiency roll-off

[59] Achieving non-doped deep-blue OLEDs by applying bipolar imidazole derivatives

[60] A DFT Study of Pyrrole-Isoxazole Derivatives as Chemosensors for Fluoride Anion

[61] Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus.

[62] Synthesis and Characterization of Fluorine-Containing Polybenzoxazoles by High-Temperature Direct Polycondensation

[63] Simultaneous removal of metronidazole and Pb(II) from aqueous solution onto bifunctional activated carbons.

[64] Biodegradation of carbazole by a promising gram-negative bacterium

[65] The Effect of Propiconazole and Protective Effects of Selenium Gene Expression Profile of Caspase 9 in the Testicular Tissue of Male Sprague Dawley (SD) Rats

[66] One-pot Microwave-Assisted Synthesis of 1H-Phenanthro[9,10- d][1,2,3]triazole

[67] Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

[68] 5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism

[69] Synthesis and structure of some new Schiff bases, derivatives of 2-((4-((R-benzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

[70] Facile Synthesis, Characterization of New Quinazolinones with Different Azo Compounds, 1,2,3-Triazole Moieties and Evaluation Their Anti-bacterial Activity.

[71] Novel acyclonucleoside analog bearing a 1,2,4-triazole–Schiff base: Synthesis, characterization and analytical studies using square wave-adsorptive stripping voltammetry and HPLC

[72] Diuretic activity of 2-((4-amino-5-R-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

[73] Synthesis and biological evaluation of benzimidazole-linked 1,2,3-triazole congeners as agents.

[74] Synthesis of somenew hybride molecules containing several azole moieties and investigation of their biological activities.

[75] Degradation rates of benzotriazoles and benzothiazoles under UV-C irradiation and the advanced oxidation process UV/H2O2.

[76] [Microbiological efficacy of a one-day treatment with triazole antimycotic I traconazole in mycotic colpitis].

[77] 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.

[78] Ni(II), Pd(II) and Pt(II) complexes of (1H-1,2,4-triazole-3-ylimino)methyl]naphthalene-2-ol. Structural, spectroscopic, biological, cytotoxicity, antioxidant and DNA binding.

[79] Novel agonists of benzodiazepine receptors: design, synthesis, binding assay and pharmacological evaluation of 1,2,4-triazolo[1,5-a]pyrimidinone and 3-amino-1,2,4-triazole derivatives.

[80] Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.

[81] Recent advances bioactive 1,2,4-triazole-3-thiones.

[82] Acid-mediated synthesis of fully substituted 1,2,3-triazoles: Multicomponent coupling reactions, mechanistic study, synthesis of serine hydrolase inhibitor and its derivatives

[83] Metal-free C-N- and N-N-bond formation: Synthesis of 1,2,3-triazoles from ketones, N-tosylhydrazines, and amines in one pot

[84] Enamine/enolate-mediated organocatalytic azide- Carbonyl [3+2] cycloaddition reactions for the synthesis of densely functionalized 1,2,3-triazoles

[85] Regioselective click chemistry for construction of arylpiperazinyl 1,2,3-triazole derivative libraries as dopamine D<inf>4</inf>/D<inf>3</inf> receptor ligands

[86] Synthesis of N -acylamidines via rhodium-catalyzed reaction of nitrosobenzene derivatives with N -sulfonyl-1,2,3-triazoles

[87] 'Green' synthesis of 1,4-disubstituted 5-iodo-1,2,3-triazoles under neat conditions, and an efficient approach of construction of 1,4,5-trisubstituted 1,2,3-triazoles in one pot

[88] An enolate-mediated organocatalytic Azide-Ketone [3+2]-cycloaddition reaction: Regioselective high-yielding synthesis of fully decorated 1,2,3-Triazoles

[89] The structure of protonated 3-pyridyl-substituted 5-amino-1H-1,2,4-triazoles: An experimental and theoretical study

[90] An efficient protocol for domino one pot synthesis of 1,2,3-triazoles from natural organic acids and phenols

[91] Copper nanoparticles supported on agarose as a bioorganic and degradable polymer for multicomponent click synthesis of 1,2,3-triazoles under low copper loading in water

[92] Regioselective one-pot synthesis of 1,4-disubstituted 1,2,3-triazole derivatives

[93] Enhanced sensory response of quaterthiophene bearing 1,2,3-triazole moiety to explosives

[94] Diastereoselective synthesis of tetrahydrofurano- and tetrahydropyrano-dihydropyrroles containing N,O-acetal moieties via rhodium-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles with oxacycloalkenes

[95] 1H-1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation

[96] Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity

[97] Rhodium(II)-catalyzed stereocontrolled synthesis of 2-tetrasubstituted saturated heterocycles from 1-sulfonyl-1,2,3-triazoles

[98] A simple and efficient synthesis of 3,4,5-trisubstituted/N-fused 1,2,4-triazoles via ceric ammonium nitrate catalyzed oxidative cyclization of amidrazones with aldehydes using polyethylene glycol as a recyclable reaction medium

[99] Facile synthesis of pyrroles via Rh(II)-catalyzed transannulation of 1-tosyl-1,2,3-triazoles with silyl or alkyl enol ethers

[100] Polystyrene resin-supported CuI-cryptand 22 complex: A highly efficient and reusable catalyst for three-component synthesis of 1,4-disubstituted 1,2,3-triazoles under aerobic conditions in water

[101] Discovery and biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety as c-Met kinase inhibitors