Bioorganic chemistry

journal of materials chemistry b

[1] Recent advances in the synthetic and medicinal perspective of quinolones: A review.

[2] Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: copper and strontium.

[3] Structures and biological evaluation of phenylpropanoid derivatives from Murraya koenigii.

[4] Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives.

[5] New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors

[6] Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.

[7] Biological evaluation of rare earth complexes bearing 1H-imidazo[4,5-f]-1,10-phenanthroline moiety as promising anticancer chemotherapeutics

[8] Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physico-chemical properties

[9] Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents.

[10] Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors.

[11] Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase.

[12] Design, synthesis and biological evaluation of novel flavone Mannich base derivatives as potential antibacterial agents

[13] Synthesis, biological evaluation and docking studies of chalcone and flavone analogs as antioxidants and acetylcholinesterase inhibitors

[14] Synthesis and biological evaluation of novel flavone/triazole/benzimidazole hybrids and flavone/isoxazole-annulated heterocycles as antiproliferative and antimycobacterial agents

[15] Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.

[16] Synthesis and biological evaluation of benzimidazole-linked 1,2,3-triazole congeners as agents.

[17] Discovery and biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety as c-Met kinase inhibitors

[18] Synthesis and biological evaluation of 2.4 nm thiolate-protected gold nanoparticles conjugated to Cetuximab for targeting glioblastoma cancer cells via the EGFR.

[19] Synthesis and Biological Evaluation of Novel 6-Hydroxy-benzo[d][1,3]oxathiol-2-one Schiff Bases as Potential Anticancer Agents

[20] Biological Evaluation and Docking Studies of Synthetic Oleanane-type Triterpenoids.

[21] Synthesis and biological evaluation of novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one schiff bases as potential anticancer agents

[22] Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors.

[23] Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC–Asef interaction

[24] Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies

[25] Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential

[26] Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization.

[27] Synthesis, Biological Evaluation and In Silico Computational Studies of 7-Chloro-4-(1-1,2,3-triazol-1-yl)quinoline Derivatives: Search for New Controlling Agents against (Lepidoptera: Noctuidae) Larvae.

[28] Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors.

[29] Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains

[30] Synthesis and biological evaluation of bergenin-1,2,3-triazole hybrids as novel class of anti-mitotic agents

[31] Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids

[32] The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents

[33] The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents

[34] Synthesis and Biological Evaluation of 7-O-Modified Formononetin Derivatives

[35] Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper

[36] Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates

[37] Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs.

[38] Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes.

[39] Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents.

[40] Synthesis, characterization, biological evaluation and docking studies of organo phosphorous pyrazole5-one derivatives of Isatine Mannich bases derivatives of sortase A staphylococcus inhibitors

[41] Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction

[42] Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001

[43] Green Bio-Assisted Synthesis, Characterization and Biological Evaluation of Biocompatible ZnO NPs Synthesized from Different Tissues of Milk Thistle ().

[44] Physical and Radiobiological Evaluation of Accelerated Intensity Modulated Radiotherapy for Locally Advanced Head and Neck Cancer and Comparison with Short-Term Clinical Outcomes.

[45] Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation.

[46] Physico-Chemical and Biological Evaluation of PLCL/SF Nanofibers Loaded with Oregano Essential Oil

[47] Chemical and biological evaluation of essential oil from Saussurea costus (Falc.) Lipsch. from Garhwal Himalaya collected at different harvesting periods

[48] Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.

[49] Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa).

[50] Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents.

[51] Synthesis and biological evaluation of metal complexes with pyrazoline derivative bearing indole and naphthyl moieties

[52] Optimization of the Extraction Conditions and Biological Evaluation of <i>Dendropanax morbifera</i> H. Lev as an Anti-Hyperuricemic Source

[53] Design and Biological Evaluation of m-Xylene Thioether-stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.

[54] New thiosemicarbazide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: Design, synthesis, and biological evaluation

[55] Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors

[56] Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents

[57] Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents.

[58] Synthesis, biological evaluation and computational studies of fused acridine containing 1,2,4-triazole derivatives as anticancer agents

[59] Synthesis, computational quantum chemical study, in silico ADMET and molecular docking analysis, in vitro biological evaluation of a novel sulfur heterocyclic thiophene derivative containing 1,2,3-triazole and pyridine moieties as a potential human topoisomerase IIα inhibiting anticancer agent

[60] Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents

[61] Synthetic studies on 3-aryloxyethyl-4-arylidene amino-5-mercapto-1,2,4-triazoles and biological evaluation as antifungal and antibacterial agents

[62] Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents.

[63] Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.

[64] Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents.

[65] Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents.

[66] Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity

[67] Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-1,2,4-triazole-3-thione/thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity

[68] Design, synthesis and biological evaluation of 1H-1,2,3-triazole-linked- 1H-dibenzo[b,h]xanthenes as inductors of ROS-mediated apoptosis in the breast cancer cell line MCF-7

[69] Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents

[70] Novel pyrimidine-2,4-dione–1,2,3-triazole and furo[2,3-d]pyrimidine-2-one–1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation

[71] Corrigendum to ‘Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA’ (Bioorganic &amp; Medicinal Chemistry Letters (2019) 29(10) (1246–1255), (S0960894X19300617), (10.1016/j.bmcl.2019.01.040))

[72] Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA

[73] Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae.

[74] Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agents

[75] Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

[76] Synthesis and biological evaluation of novel disulfides incorporating 1,3,4-thiadiazole scaffold as promising antitumor agents

[77] Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.

[78] Biological evaluation, molecular docking and DNA interaction studies of coordination compounds gleaned from a pyrazolone incorporated ligand

[79] Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and biological evaluation.

[80] Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors

[81] Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives

[82] Glycerol Mediated Synthesis, Biological Evaluation, and Molecular Docking Study of 4-(1H-pyrazol-4-yl)-polyhydroquinolines as Potent Antitubercular Agents

[83] Novel phthalimide based analogues: design, synthesis, biological evaluation, and molecular docking studies.

[84] Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

[85] Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation.

[86] Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents.

[87] Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation

[88] Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3).

[89] Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3)

[90] Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors.

[91] Synthesis, in vitro biological evaluation and in silico molecular docking studies of novel β-lactam-anthraquinone hybrids.

[92] Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.

[93] Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M muscarinic acetylcholine receptors.

[94] Corrigendum to “Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors” (European Journal of Medicinal Chemistry (2019) 180 (171–190), (S0223523419306488), (10.1016/j.ejmech.2019.07.026))

[95] Corrigendum to &lt;‘Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d] pyrimidine analogues as novel CHK1 inhibitors’ [Eur. J. Med. Chem. 151 (2018) 836–848] (European Journal of Medicinal Chemistry (2018) 151 (836–848), (S0223523418303192), (10.1016/j.ejmech.2018.03.075))

[96] Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.

[97] Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles.

[98] 4-(2-(1-Benzo[]imidazol-2-ylthio)acetamido)--(substituted phenyl)benzamides: design, synthesis and biological evaluation.

[99] Developing a biopolymeric chitosan supported Schiff-base and Cu(II), Ni(II) and Zn(II) complexes and biological evaluation as pro-drug

[100] Corrigendum to “Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation”. (Bioorganic Chemistry (2020) 94, (S0045206819313793), (10.1016/j.bioorg.2019.103387))

[101] Design, synthesis,: In silico docking studies and biological evaluation of novel quinoxaline-hydrazide hydrazone-1,2,3-triazole hybrids as α-glucosidase inhibitors and antioxidants