The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin.

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2020
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Abstract
The  Chinese  tree  shrew  ()  is  a small mammal closely related to primates. It has a small body size, low maintenance cost, and a relatively short reproductive cycle, all of which has made it the ideal model for the study of a variety of human diseases. In this study, we compared the anatomy  of  the  skin  of  the  Chinese  tree  shrew  with  that  of rhesus  macaque,  mouse  and  human,  with  the  intention  of providing  the  basic  data  required  for  the  creation  of  skin disease  models  using  this  animal.  Paraffin  sections, hematoxylin-eosin staining, masson staining and immunohistochemical  techniques  were  used  to  examine  the dorsal skin structure of the Chinese tree shrew. The epidermis was shown to be composed of 1-2 layers of cells. There were hair  follicles,  sebaceous  glands  and  sweat  glands  in  the dermis  and  the  subcutaneous  tissue,  with  apocrine  glands being  more  common  than  eccrine  glands.  Both  Keratin5 (KRT5) and Keratin10 (KRT10) were expressed in the skin of the Chinese tree shrew, with a localization in the cytoplasm. Overall, the skin morphology and histology of the Chinese tree shrew  was  basically  the  same  as  that  of  the  human.  We propose that the Chinese tree shrew has a strong potential to be  used  for  creating  animal  models  to  help  elucidate  the molecular mechanisms underlying a variety of skin diseases.
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zhang2020thezoological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Jing;Luo, Rong-Can;Man, Xiao-Yong;Lv, Long-Bao;Yao, Yong-Gang;Zheng, Min;
Journal zoological research
Year 2020
DOI
2095-8137(2020)00-0001-05
URL
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