State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

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ID: 9991
2019
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Abstract
The optical imaging plays an increasing role in preclinical studies, particularly in cancer biology. The combined ultrasound and optical imaging, named photoacoustic imaging (PAI), is an emerging hybrid technique for real-time molecular imaging in preclinical research and recently expanding into clinical setting. PAI can be performed using endogenous contrast, particularly from oxygenated and deoxygenated hemoglobin and melanin, or exogenous contrast agents, sometimes targeted for specific biomarkers, providing comprehensive morphofunctional and molecular information on tumor microenvironment. Overall, PAI has revealed notable opportunities to improve knowledge on tumor pathophysiology and on the biological mechanisms underlying therapy. The aim of this review is to introduce the principles of PAI and to provide a brief overview of current PAI applications in preclinical research, highlighting also on recent advances in clinical translation for cancer diagnosis, staging, and therapy.
Reference Key
sara2019stateoftheartcontrast Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gargiulo, Sara;Albanese, Sandra;Mancini, Marcello;Gargiulo, Sara;Albanese, Sandra;Mancini, Marcello;
Journal contrast media & molecular imaging
Year 2019
DOI
10.1155/2019/5080267
URL
https://www.hindawi.com/journals/cmmi/2019/5080267/abs/
Keywords Keywords not found

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