Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
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ID: 98917
2012
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Abstract
Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
| Reference Key |
zhang2012synthesismolecules
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| Authors | Zhang, Ke-Hua;Xia, Jing-Jing; |
| Journal | molecules |
| Year | 2012 |
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