Cu(II) Schiff base complex as a highly efficient catalyst for the synthesis of polyhydroquinoline derivatives via Hantzsch condensation in water.

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ID: 98895
2013
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Abstract
In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.
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vahdat2013cuiicombinatorial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Vahdat, Seyed Mohammad;
Journal combinatorial chemistry & high throughput screening
Year 2013
DOI
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Keywords
Antimicrobial activity multicomponent reaction antimalarial activity 5-imidazopyrazole incorporated polyhydroquinolines antituberculosis activity

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