Lumbar spondylolysis: A report of four cases from two generations of a family

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ID: 98632
2017
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Abstract
Spondylolysis is a major cause of back pain in children and adolescents. The prevalence of spondylolysis depends on the sex, race, and congenital abnormality. These biases suggest hereditary predisposition as an etiology of spondylolysis. However, no conclusive evidence still exists regarding the inheritance for spondylolysis. Herein, we report rare cases with familial occurrence of lumbar spondylolysis. In two generations of a Japanese family, three brothers including identical twins complained of back pain related to sports activities. Clinical, radiographic, and computed tomographic examinations identified spondylolysis at L4 and L5 in all these boys. The father experienced long-term back pain and had spondylolisthesis at L4–L5 and healed spondylolysis at L5. The daughter and mother did not show any lumbar spondylolysis. The frequent development of spondylolysis at L4, a rarely affected segment, in four of six family members (66.7%) support that lumbar spondylolysis has an underlying genetic etiology, primarily autosomal dominant inheritance.
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yurube2017lumbarjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yurube, Takashi;Kakutani, Kenichiro;Okamoto, Koji;Manabe, Michihiko;Maeno, Koichiro;Yoshikawa, Masaho;Sha, Norihide;Kuroda, Ryosuke;Nishida, Kotaro;
Journal journal of orthopaedic surgery
Year 2017
DOI
DOI not found
URL
https://doi.org/10.1177/2309499017713917
Keywords
Education Therapeutics. Pharmacology Medicine Technology Science environmental sciences neoplasms. tumors. oncology. including cancer and carcinogens nutrition. foods and food supply education (general) anesthesiology orthopedic surgery geography. anthropology. recreation

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