The release from refractoriness hypothesis of N1 of event-related potentials needs reassessment.

Clicks: 273
ID: 98434
2020
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Abstract
N1 of event-related potentials (ERPs) is augmented in amplitude in ∼50-150 ms by occasional changes (deviants) in the physical features of a sound repeated at intervals of from ∼400 ms to seconds (standard). The release-from-refractoriness hypothesis links the N1 augmentation to a deviant-feature-specific neural population that is fresh to fully respond as opposed to a standard-feature-specific neural population that is unresponsive due to its post-response refractoriness. The present work explored this hypothesis in the context of ERP studies, behavioral habituation studies and studies on stimulus-specific adaptation (SSA). The idea of hundreds of milliseconds neural population-level refractoriness was observed to be founded upon negative N1 evidence (no observable effect of dishabituating stimuli on N1 to standards - the null hypothesis retained) and merely supported by positive N1 evidence (null hypotheses rejected). This idea was also found to be directly challenged by positive N1 evidence. No conclusive network- or single-neuron-level evidence was found for the refractoriness. Therefore, the validity of the release-from-refractoriness hypothesis of N1 to guide psychophysiological research needs reassessment.
Reference Key
ruusuvirta2020thehearing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ruusuvirta, Timo;
Journal hearing research
Year 2020
DOI
S0378-5955(19)30441-1
URL
Keywords
adaptation event-related potential habituation mismatch negativity (mmn) dishabituation n1 neural fatigue stimulus-specific adaptation (ssa)

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