Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.

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ID: 98412
2018
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Abstract
Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.
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toptan2018limitedplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Toptan, Tuna;Brusadelli, Marion G;Turpin, Brian;Witte, David P;Surrallés, Jordi;Velleuer, Eunike;Schramm, Martin;Dietrich, Ralf;Brakenhoff, Ruud H;Moore, Patrick S;Chang, Yuan;Wells, Susanne I;
Journal PloS one
Year 2018
DOI
DOI not found
URL
http://europepmc.org/articles/PMC6307729?pdf=render
Keywords
Biology (General) Medicine Science Diseases of the blood and blood-forming organs genetics

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