Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

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ID: 98411
2012
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Abstract
The Fanconi Anemia (FA) pathway consists of proteins involved in repairing DNA damage, including interstrand cross-links (ICLs). The pathway contains an upstream multiprotein core complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and a downstream pathway that converges with a larger network of proteins with roles in homologous recombination and other DNA repair pathways. Selective killing of cancer cells with an intact FA pathway but deficient in certain other DNA repair pathways is an emerging approach to tailored cancer therapy. Inhibiting the FA pathway becomes selectively lethal when certain repair genes are defective, such as the checkpoint kinase ATM. Inhibiting the FA pathway in ATM deficient cells can be achieved with small molecule inhibitors, suggesting that new cancer therapeutics could be developed by identifying FA pathway inhibitors to treat cancers that contain defects that are synthetic lethal with FA.
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jenkins2012targetinganemia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jenkins, Chelsea;Kan, Jenny;Hoatlin, Maureen E.;
Journal anemia
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/481583
Keywords
Biology (General) Science Diseases of the blood and blood-forming organs genetics

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