Role of RUNX Family Transcription Factors in DNA Damage Response.

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ID: 98382
2020
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Abstract
Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi anemia pathways. In this review, we discuss the functional role and mechanisms involved in RUNX factor mediated response to DNA damage and other cellular stresses. We highlight the impact of these new findings on our understanding of cancer predisposition associated with RUNX factor dysregulation and their implications for designing novel approaches to prevent cancer formation in affected individuals.
Reference Key
samarakkody2020rolemolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Samarakkody, Ann Sanoji;Shin, Nah-Young;Cantor, Alan B;
Journal molecules and cells
Year 2020
DOI
10.14348/molcells.2019.0304
URL
Keywords
Cancer p53 cell cycle arrest runx2 dna damage response fanconi anemia runx1 runx3 tumor suppressor

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