Characteristics of the nerve barrier and the blood dorsal root ganglion barrier in health and disease.

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ID: 97979
2020
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Abstract
A variety of barriers ensures the protection of the peripheral nervous system from noxious blood-borne or surrounding stimuli. In this review, anatomy and functioning of the blood nerve barrier (BNB) and the blood DRG barrier (BDB) will be presented and key tight junction proteins described: ZO-1, claudin-1, -3, -5, -11, -12, -19, occludin, and tricellulin. Different diseases can lead to or be accompanied by nerve barrier disruption; impairment of nerve barriers in turn worsens pathology. Peripheral nerve injury, diabetic neuropathy and inflammatory polyneuropathy cause an increased permeability of BNB and BDB. Knowledge and understanding of these mechanisms might ultimately lead to the invention of drugs to control barrier function and help ameliorating neurological diseases.
Reference Key
reinhold2020characteristicsexperimental Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Reinhold, A K;Rittner, H L;
Journal experimental neurology
Year 2020
DOI
S0014-4886(20)30075-3
URL
Keywords
diabetic neuropathy nerve injury tight junction claudin zo-1 blood dorsal root ganglion barrier blood nerve barrier inflammatory polyneuropathy occludin tricellulin

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