Prefrontal cortex projections to the nucleus reuniens suppress freezing following two-way signaled avoidance training.

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ID: 97676
2020
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Abstract
Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited following SAA training to suppress freezing in rats. This projection may serve as a crucial common pathway for the inhibition of innate defensive reactions that interfere with proactive behavior, thus facilitating adaptive coping.
Reference Key
moscarello2020prefrontallearning Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Moscarello, Justin M;
Journal learning & memory (cold spring harbor, ny)
Year 2020
DOI
10.1101/lm.050377.119
URL
Keywords
oxidative damage atherosclerosis acute phase protein renal inflammation

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