Metabolic and Biomolecular Changes Induced by Incremental Long-Term Training in Young Thoroughbred Racehorses during First Workout Season.

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ID: 97672
2020
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Abstract
Training has a huge effect on physiological homeostasis. The Thoroughbred racehorse is a valid animal model to investigate such changes for training schedule fine-tuning. As happens in human athletes, it is hypothesized that biochemical and immune response changes and related biomolecular variations could be induced by training programs. The aim of this study was to investigate, for the first time, the long-term metabolic and biomolecular modifications in young untrained Thoroughbred racehorses in the first 4-month timeframe training period. Twenty-nine clinically healthy, untrained, two-year-old Thoroughbred racehorses were followed during their incremental 4-month sprint exercise schedule. Blood collection was performed once a month, five times (T-30, T0, T30, T60, and T90). For each sample, lactate concentration, plasma cell volume (PCV), and hematobiochemical parameters (glucose, urea, creatinine, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (Tbil), lactate dehydrogenase (LDH), creatine kinase (CK), cholesterol, triglycerides, albumin (Alb), total proteins (TPs), phosphorus (P), calcium (Ca), magnesium (Mg), sodium (Na), potassium (K), and chloride (Cl)) were determined. At T-30 and T90, serum protein electrophoresis (SPE), serum amyloid A (SAA), and real-time qPCR were performed on all samples to evaluate the expression of key genes and cytokines related to inflammatory and Th2 immunity responses: Interleukin-4 (), Interleukin-6 (), Interleukin-10 (), Interleukin-1β (), Octamer-Binding Transcription Factor 1 (), B-cell lymphoma/leukemia 11A (). Statistical analysis was performed (ANOVA and test, < 0.05). Significant modifications were identified compared with T-30 for PCV, glucose, triglycerides, cholesterol, lactate, urea, creatinine, Tbil, ALP, LDH, Na, K, Ca, SAA, TPs, SPE, --, , and BCL. In conclusion, the first long-term training period was found to induce fundamental systemic changes in untrained Thoroughbreds.
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miglio2020metabolicanimals Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Miglio, Arianna;Cappelli, Katia;Capomaccio, Stefano;Mecocci, Samanta;Silvestrelli, Maurizio;Antognoni, Maria Teresa;
Journal animals
Year 2020
DOI
E317
URL
Keywords
thoroughbred racehorses biomolecular changes immunological adaptations long-term training metabolic modifications sprint exercise

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