Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair.

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ID: 97621
2020
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Abstract
Hair analysis has been an important approach in evaluating population exposure to various environmental factors. To meet the requirements of human environmental epidemiology studies, we aimed to develop an efficient method for simultaneous analysis of various metal(loid)s and some typical environmental halogenated endocrine disrupting chemicals (hEDCs) (i.e., polychlorinated biphenyls, polybrominated diphenyl ethers, and organochlorine pesticides, as well as some of their hydroxyl substituted metabolites) in a single hair sample. The hair was washed successively with surfactant solutions, methanol solvent, and deionized water to remove impurities attached to the hair surface. Efficiency was comprehensively compared among various washing strategies. The hair sample was further pulverized into fine powder with a median diameter (25th-75th percentile) of 8.6 (5.9-13.5) μm. The hair organic components were extracted by acetonitrile solvent and compared with the microwave-assisted extraction method. The hEDCs in the supernatant acetonitrile phase were quantified by gas chromatography-mass spectrometry, and the metal(loid)s in the precipitate hair were further analyzed by inductively coupled plasma mass spectrometry. Our developed method was further applied to analyze the hair samples of 165 pregnant women. The results showed that particles attached to the surface of the hair could not be washed off completely. However, we proposed a protocol framework to wash hair with relatively high efficience, which includes warm water incubation, and use of surfactant and organic solvent. The recoveries of the concerned hEDCs and metal(loid)s were overall in the range of 80% to 120%. For the women population, the method can efficiently recognize the typical exposure characteristics of the concerned hEDCs and metal(loid)s. Our study significantly ameliorated the deficiencies of the traditional hair washing strategy and developed an efficient method for simultaneous analysis of various metal(loid)s and hEDCs in a single hair sample. This method will provide important support for population complex exposure analysis and facilitate environmental exposome studies.
Reference Key
ren2020simultaneousthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ren, Mengyuan;Jia, Xiaoqian;Shi, Jiazhang;Yan, Lailai;Li, Zewu;Lan, Changxin;Chen, Junxi;Li, Nan;Li, Kexin;Huang, Jing;Wu, Shaowei;Lu, Qun;Li, Zhiwen;Wang, Bin;Liu, Jianmeng;
Journal The Science of the total environment
Year 2020
DOI
S0048-9697(20)30810-X
URL
Keywords
endocrine disrupting chemicals hair metal(loid)s exposome simultaneous analysis

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