Radiofrequency-triggered tumor-targeting delivery system for theranostics application.

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ID: 97606
2015
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Abstract
In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.
Reference Key
wang2015radiofrequencytriggeredacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Lei;Zhang, Panpan;Shi, Jinjin;Hao, Yongwei;Meng, Dehui;Zhao, Yalin;Yanyan, Yin;Li, Dong;Chang, Junbiao;Zhang, Zhenzhong;
Journal ACS applied materials & interfaces
Year 2015
DOI
10.1021/am507898z
URL
Keywords
controlled release chemo-hyperthermia therapy dual-mode mr/x-ray imaging gold nanoshells thermosensitive magnetoliposomes

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