Radiofrequency-triggered tumor-targeting delivery system for theranostics application.

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ID: 97606
2015
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Abstract
In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.
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wang2015radiofrequencytriggeredacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Lei;Zhang, Panpan;Shi, Jinjin;Hao, Yongwei;Meng, Dehui;Zhao, Yalin;Yanyan, Yin;Li, Dong;Chang, Junbiao;Zhang, Zhenzhong;
Journal ACS applied materials & interfaces
Year 2015
DOI
10.1021/am507898z
URL
Keywords
controlled release chemo-hyperthermia therapy dual-mode mr/x-ray imaging gold nanoshells thermosensitive magnetoliposomes

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