Multimodal Imaging Probe Development for Pancreatic β Cells: From Fluorescence to PET.

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ID: 97484
2020
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Abstract
Pancreatic β cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers for diabetes have been glucose and insulin concentrations in the blood, the direct determination of the pancreatic β cell mass would provide critical information for the disease status and progression. By combining fluorination and diversity-oriented fluorescence library strategy, we have developed a multimodal pancreatic β cell probe for both fluorescence and for PET (positron emission tomography). By simple tail vein injection, stains pancreatic β cells specifically and allows intraoperative fluorescent imaging of pancreatic islets. -injected pancreatic tissue even facilitated an antibody-free islet analysis within 2 h, dramatically accelerating the day-long histological procedure without any fixing and dehydration step. Not only islets in the pancreas but also the low background of in the liver allowed us to monitor the intraportal transplanted islets, which is the first in vivo visualization of transplanted human islets without a prelabeling of the islets. Finally, we could replace the built-in fluorine atom in with radioactive 18F and successfully demonstrate in situ PET imaging for pancreatic islets.
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kang2020multimodaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kang, Nam-Young;Lee, Jung Yeol;Lee, Sang Hee;Song, In Ho;Hwang, Yong Hwa;Kim, Min Jun;Phue, Wut Hmone;Agrawalla, Bikram Keshari;Wan, Si Yan Diana;Lalic, Janise;Park, Sung-Jin;Kim, Jong-Jin;Kwon, Haw-Young;Im, So Hee;Bae, Myung Ae;Ahn, Jin Hee;Lim, Chang Siang;Teo, Adrian Kee Keong;Park, Sunyou;Kim, Sang Eun;Lee, Byung Chul;Lee, Dong Yun;Chang, Young-Tae;
Journal Journal of the American Chemical Society
Year 2020
DOI
10.1021/jacs.9b11173
URL
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