Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats.

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ID: 96872
2020
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Ranked #2 of 7 articles by views in Biotechnic & histochemistry : official publication of the Biological Stain Commission

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Abstract
We investigated the effects of artemisinin on doxorubicin (Dox) induced heart and liver pathology in rats. We divided 49 male rats into seven groups: group 1 was the untreated control. Dox was administered intraperitoneally to groups 2, 3 and 4 on day 1. Artemisinin was administered by gavage to groups 3 and 6 at a dose of 7 mg/kg, and to groups 4 and 7 at a dose of 35 mg/kg for 14 days. Group 5 was given only 0.9% NaCl orally for 14 days. At the end of the study, heart and liver samples were collected for histopathology and immunohistochemistry. Hyperemia and slight hemorrhages were observed in both livers and hearts of rats treated with Dox only. Significant increases in caspase-3, TNF-α, iNOS and NF-κB expression were observed in the myocardial cells and hepatocytes of group 2. Significant reductions in caspase-3, TNF-α, iNOS and NF-κB expression were observed in groups 3 and 4 following artemisinin treatment compared to group 2. Artemisinin may exert protective effects against Dox induced cardiotoxicity and hepatotoxicity in rats.
Reference Key
aktas2020artemisininbiotechnic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Aktaş, I;Özmen, Ö;Tutun, H;Yalçın, A;Türk, A;
Journal Biotechnic & histochemistry : official publication of the Biological Stain Commission
Year 2020
DOI
10.1080/10520295.2019.1647457
URL
Keywords
TNF-α caspase-3 liver doxorubicin artemisinin nf-κb heart inos

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