A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH

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ID: 96824
2004
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Abstract

Abstract

In a previous study, a model was developed to investigate the release of luteinizing hormone (LH) from pituitary cells in response to a short pulse of gonadotropin-releasing hormone (GnRH). The model included: binding of GnRH to its receptor (R), dimerization and internalization of the hormone receptor complex, interaction with a G protein, production of inositol 1,4,5-trisphosphate (IP3), release of calcium from the endoplasmic reticulum (ER), entrance of calcium into the cytosol via voltage gated membrane channels, pumping of calcium out of the cytosol via membrane and ER pumps, and release of LH. The extended model, presented in this paper, also includes the following physiologically important phenomena: desensitization of calcium channels; internalization of the dimerized receptors and recycling of some of the internalized receptors; an increase in Gq concentration near the plasma membrane in response to receptor dimerization; and basal rates of synthesis and degradation of the receptors. With suitable choices of the parameters, good agreement with a variety of experimental data of the LH release pattern in response to pulses of various durations, repetition rates, and concentrations of GnRH were obtained. The mathematical model allows us to assess the effects of internalization and desensitization on the shapes and time courses of LH response curves.

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c2004atheoretical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C, Reed Michael;Joseph, Blum J;M, Washington Talitha;Michael, Conn P;
Journal theoretical biology and medical modelling
Year 2004
DOI
DOI not found
URL
http://www.tbiomed.com/content/1/1/9
Keywords
Biology (General) Medicine Computer applications to medicine. Medical informatics Mineralogy chemical engineering economic growth, development, planning mining engineering. metallurgy regional economics. space in economics english literature american literature

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