Blood Viral Load in Symptomatic Congenital Cytomegalovirus Infection.

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ID: 96445
2019
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Abstract
Viral loads (VLs) frequently are followed during treatment of symptomatic congenital cytomegalovirus disease, but their predictive value is unclear.Post hoc analysis of 2 antiviral studies was performed. Seventy-three subjects were treated for 6 weeks and 47 subjects were treated for 6 months. Whole blood VL was determined by real-time polymerase chain reaction before and during therapy.Higher baseline VL was associated with central nervous system involvement (3.82 log, range 1-5.65 vs 3.32 log, range 1-5.36; P = .001), thrombocytopenia (3.68 log, range 1-5.65 vs 3.43 log, range 1-5.36; P = .03), and transaminitis at presentation (3.73 log, range 1-5.60 vs 3.39 log, range 1-5.65; P = .009), but with overlap in the amount of virus detected between groups. In subjects treated for 6 months, lower VL at presentation correlated with better hearing outcomes at 12 months, but VL breakpoints predictive of hearing loss were not identified. Sustained viral suppression during 6 months of therapy correlated with better hearing outcomes at 6, 12, and 24 months (P = .01, P = .0007, P = .04), but a majority without viral suppression still had improved hearing.In infants with symptomatic congenital cytomegalovirus disease, higher whole blood VL before initiation of antiviral therapy has no clinically meaningful predictive value for long-term outcomes.
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marsico2019bloodthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marsico, Concetta;Aban, Immaculada;Kuo, Huichien;James, Scott H;Sanchez, Pablo J;Ahmed, Amina;Arav-Boger, Ravit;Michaels, Marian G;Ashouri, Negar;Englund, Janet A;Estrada, Benjamin;Jacobs, Richard F;Romero, José R;Sood, Sunil K;Whitworth, Suzanne;Jester, Penelope M;Whitley, Richard J;Kimberlin, David W;, ;
Journal The Journal of infectious diseases
Year 2019
DOI
10.1093/infdis/jiy695
URL
Keywords
antiviral therapy viral load hearing loss congenital cmv infection

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