The Challenge of Treatment in Potential Celiac Disease.

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ID: 96254
2019
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Abstract
Potential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1). This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge. We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database. Accordingly, we identified different genetic features in patients with PCD compared to the classical forms. Frequently, signs of inflammation (deposits of immunoglobulin A (IgA) and/or increased number of intraepithelial lymphocytes) can be clearly identify in the mucosa of PCD patients after an accurate histological assessment. Finally, the main challenge is represented by the treatment: the gluten-free diet should be considered only in the presence of gluten-dependent symptoms in both children and adults. : (i) potential celiac disease (PCD) occurs in one-fifth of all celiac diseases (CD), and (ii) despite the absence of classical lesions, clear signs of inflammation are often detectable. : (i) patients with PCD show different genetic features, and (ii) the presence of gluten-dependent symptoms is the main determinant to initiate the gluten-free diet, after a complete diagnostic work-up.
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trovato2019thegastroenterology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Trovato, Chiara Maria;Montuori, Monica;Valitutti, Francesco;Leter, Beatrice;Cucchiara, Salvatore;Oliva, Salvatore;
Journal gastroenterology research and practice
Year 2019
DOI
10.1155/2019/8974751
URL
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