Synthesis and Antimicrobial Activity of Benzimidazole-Based Acetamide Derivatives

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ID: 96136
2015
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Abstract
In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 μg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 μg/mL when compared with ketoconazole (MIC= 62.5 μg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL
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altintop2015synthesisturkish Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mehlika Dilek Altintop, Usama Abu Mohsen, Yusuf Özkay, Rasime Demi̇rel, Zafer Asım Kaplancikli
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Journal Turkish journal of pharmaceutical sciences
Year 2015
DOI
DOI not found
URL
http://www.turkjps.org/archives/archive-detail/article-preview/synthesis-and-antimicrobial-activity-of-benzimidaz/12322
Keywords
chemistry Pharmacy and materia medica Therapeutics. Pharmacology Biology (General) Chemical technology Engineering (General). Civil engineering (General) Science (General) Science nutrition. foods and food supply

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