Synthesis and Antimicrobial Activity of Benzimidazole-Based Acetamide Derivatives

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ID: 96136
2015
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Abstract
In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising antibacterial agents against Pseudomonas aeruginosa. These compounds and streptomycin exhibited the same level of antibacterial activity with a MIC value of 125 μg/mL. Compounds 2p, 2s, 2t and 2u were the most potent antifungal derivatives against Candida krusei with a MIC value of 125 μg/mL when compared with ketoconazole (MIC= 62.5 μg/mL). Compounds 2s and 2u also exhibited the highest inhibitory activity against Fusarium solani with a MIC value of 125 μg/mL, whereas ketoconazole showed its antifungal activity with a MIC value of 62.5 μg/mL
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altintop2015synthesisturkish Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ALTINTOP, Mehlika Dilek;MOHSEN, Usama ABU;ÖZKAY, Yusuf;DEMİREL, Rasime;KAPLANCIKLI, Zafer Asım;
Journal Turkish journal of pharmaceutical sciences
Year 2015
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