Nano-SnCl.SiO, an efficient catalyst for synthesis of benzimidazole drivatives as antifungal and cytotoxic agents.

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ID: 96097
2019
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Abstract
The concept of green chemistry has made significant impact on many frontages including the use of green solvents or sustainable catalyst materials. Benzimidazole ring is an important nitrogen-containing heterocyclic, which exhibits a broad spectrum of bioactivities and are widely utilized by the medicinal chemists for drug discovery. A simple and efficient method was developed for the synthesis of some benzimidazole derivatives reaction of -phenylenediamine and substituted aldehydes in the presence of nano-SnCl/SiO as a mild catalyst. Ten 2-substituted benzimidazole compounds ( ) were synthesized. All compounds were evaluated against different species of yeasts and filament fungi using broth micro dilution method as recommended by clinical and laboratory standard institute. Among these compounds, the active ones were chosen for their cytotoxic activities evaluation against MCF-7 and A549 cell lines using MTT method. Compound showed the best antifungal activity against all tested species. Compounds had also desirable antifungal activities. Our cytotoxic results were also similar to the antifungal activities except for which had no cytotoxic activity.
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zamani2019nanosnclsioresearch Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zamani, Leila;Faghih, Zeinab;Zomorodian, Kamiar;Mirjalili, Bi Bi Fatemeh;Jalilian, Asghar;Khabnadideh, Soghra;
Journal research in pharmaceutical sciences
Year 2019
DOI
10.4103/1735-5362.272536
URL
Keywords
cytotoxic benzimidazole mtt antifungal nano-sncl4/sio2

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