Effects of RO27-3225 on neurogenesis, PDGFRβ cells and neuroinflammation after cerebral infarction.

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ID: 95885
2020
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Abstract
Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumatic brain injury and chronic neurodegenerative diseases. However, the effect of RO27-3225 on cerebral infarction remains unclear. In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO) and administered RO27-3225 or saline to the mice through intraperitoneal injection. RO27-3225 increased the number of Nestin/BrdU cells and doublecortin (DCX)/BrdU cells in the subventricular zone (SVZ) and the number of DCX/BrdU cells in the peri-infarct area on day 7 after tMCAO. Furthermore, RO27-3225 decreased the number of activated microglia (Iba1 cells with a specific morphology) and the expression levels of Iba1, TNFα, IL6, and iNOS proteins and increased the number of PDGFRβ cells in the peri-infarct region on day 3 after tMCAO. Finally, RO27-3225-treated mice exhibited significantly decreased infarct volumes, brain water contents, and neurological deficits after cerebral infarction. Thus, RO27-3225 can improve the outcomes following cerebral infarction, partially by regulating neurogenesis in the SVZ, PDGFRβ cell survival and neuroinflammation in the peri-infarct zone. Our research reveals that RO27-3225 is a potential new treatment for cerebral infarction.
Reference Key
zhang2020effectsinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Yongxin;Wang, Jianping;Zhang, Di;Lu, Zhengfang;Man, Jiang;
Journal international immunopharmacology
Year 2020
DOI
S1567-5769(19)32405-1
URL
Keywords
neuroinflammation neurogenesis cerebral infarction pdgfrβ(+) cells ro27-3225 subventricular zone

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