Clinical precision, accuracy, number and durations of exhalations for a novel electrochemical monitor for exhaled nitric oxide.

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ID: 95803
2019
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Abstract
Exhaled nitric oxide (FeNO) is a validated marker of eosinophilic inflammation. Fenom Pro is a novel FDA-cleared monitor for FeNO. The American Thoracic Guidelines from 2005 recommend at least 6 s exhalation for adults and in some cases up to 10 s, and 4 s for children, and that the average of the first two valid exhalations is taken as the FeNO value.Clinical precision, 6 versus 10 s exhalations, the first versus the average of the first two valid exhalation methods comparison were evaluated for Fenom Pro, as well as a methods comparison to the NIOX VERO monitor.The intent-to-treat population (n = 126) consisted of 83 adults, and 43 pediatric subjects with 16 subjects under 12 years of age. Clinical precision for 10 s exhalations on Fenom Pro was excellent with a within-subject standard deviation (SD) range of 0.57-3.73 ppb and mean coefficient of variation (CV) range of 4.21% to 9.65%. The clinical precision for the separate adult and pediatric groups as well as for the 6 s exhalations were similar. The 10 and 6 s exhalation comparisons and one versus the average of two valid exhalations showed a high level of agreement. The Fenom Pro and the NIOX VERO monitors also demonstrated a high level of agreement with the values from the latter slightly lower (mean bias of -3.2 ppb).Fenom Pro demonstrated eminently acceptable performance supporting its clinical utility. The data suggests that 6 s exhalations can be used in adults and children, and that one exhalation is adequate rather than obtaining the average of two exhalations on Fenom Pro.
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silkoff2019clinicaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Silkoff, Philip E;Awabdy, Brian;Sarno, Mark;Ssenyange, Solomon;Balsubramanyam, Vivek;Leard, Ryan;
Journal journal of breath research
Year 2019
DOI
10.1088/1752-7163/ab5422
URL
Keywords
Atrial fibrillation Warfarin Anticoagulation thromboembolism primary care chronotherapy practice-based research coumadin ttr mechanical valve

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